Young scientist Elizabeth Barnes (Tiffany Shepis) and her group of researchers are conducting illegal stem cell research, and discover a cell anomaly that has the potential to regenerate dead tissue. Unable to conduct legal human trials, the researchers turn to corpses to test their serum.
Renowned "ghost hunter", Carter Simms is paid to conduct a paranormal investigation of a supposedly haunted house. Along with a cameraman, a reporter, and a spiritual advocate, she embarks on a three night journey into terror.